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COQ10 RED :: 100 mg 180 CAPS

COQ10 RED :: 100 mg 180 CAPS
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Description

COQ10 redCoQ10 is a natural potent antioxidant, which protects the mitochondria and the cell membrane against free radicals and oxidative damage. Mitochondria is the power house of the cell and generates energy in the form of ATP (Adenosine Tri-phosphate) by burning sugar and fat with oxygen with the help of CoQ10. Many of the symptoms of aging are the result of mitochondrial decay.

At the age of 25 our bodies produce 100% of the CoQ10 required. As we age the natural production of CoQ10 dramatically declines. Since cells require CoQ10 for energy production, the result of CoQ10 deficiency can be seen in many symptoms associated with aging. 

Aging has been associated with a reduced capacity for oxidative phosphorylation in the cells, most likely due to a decline in mitochondria content and/or function.

Research has shown that in the muscle cells, a poor capacity for oxidative metabolism is associated with Insulin Resistance and Type 2 diabetes. Recent studies further indicate that muscle mitochondria of patients with Type 2 diabetes are smaller, less in number and may also be less functional as compared to healthy people.

Minding Your Mitochondria

The ANTIAGING® Institute of California has been an advocate of Coenzyme Q10.  Our recommendation is one Softgel of 100 mg CoQ10, for men and women over the age of 40, after a meal, preferably breakfast. Depending on the body’s requirement and with your physician’s suggestions you can increase the daily dose.

The National Cancer Institute (NCI) has recently proposed a PDQ, a study to provide accurate information on the use of CoQ10.

As you know, free radicals are chemicals produced in the body through normal pathways that possess one or more unpaired electron such as O2.- , OH. and other non-radical oxygen derivatives, such as hydrogen peroxide (H2O2).

Unpaired electrons are not stable, and are highly reactive. Unstable free radicals attack stable cellular components, to gain an electron causing damage to lipids, proteins and DNA inside the cells and generating new free radicals.

In addition to normal body processes, environmental factors such as radiation, pollution, cigarette smoking, and high fat diets generate free radicals.

Because cells of the heart have high energy demands, initial clinical studies investigated the effect of CoQ10 on cardiac mitochondrial function.

CoQ10 RED is known to improve the immune profile of the skin because of its potent antioxidant effect. Because of its ANTIAGING®results on the skin, CoQ10 is added to many of the skin care products to reduce the appearance of fine lines and wrinkles. Taking 100 mg of CoQ10 RED orally provides a much higher concentration of soluble CoQ10 to the skin (face and the entire body). 

 CoQ10 RED is provided in an easy to swallow soft gel capsule with greater solubility.  Nature and nurture, together with sound scientific knowledge can accurately help prevent and postpone the signs of aging.

Coenzyme Q10 (CoQ 10) or ubiquinone is essentially a vitamin or vitamin-like substance.  Vitamins are defined as organic compounds essential in minute amounts for normal body function acting as coenzymes or precursors to coenzymes. They are present naturally in foods and sometimes are also synthesized in the body. CoQ10 likewise is found in small amounts in a wide variety of foods and is synthesized in all tissues. The biosynthesis of CoQ10 from the amino acid tyrosine is a multistage process requiring at least eight vitamins and several trace elements. Coenzymes are cofactors upon which the comparatively large and complex enzymes absolutely depend for their function. Coenzyme Q10 is the coenzyme for at least three mitochondrial enzymes (complexes I, II and III) as well as enzymes in other parts of the cell. Mitochondrial enzymes of the oxidative phosphorylation pathway are essential for the production of the high-energy phosphate, adenosine triphosphate (ATP), upon which all cellular functions depend. The electron and proton transfer functions of the quinone ring are of fundamental importance to all life forms; ubiquinone in the mitochondria of animals, plastoquinone in the chloroplast of plants, and menaquinone in bacteria.

The term "bioenergetics" has been used to describe the field of biochemistry looking specifically at cellular energy production. In the related field of free radical chemistry, CoQ10 has been studied in its reduced form as a potent antioxidant. The bioenergetics and free radical chemistry of CoQ10 are reviewed in Gian Paolo Littarru's book, Energy and Defense. Professor Littarru is the President of the International Coenzyme Q10 Association.

COENZYME Q10 is the ONLY supplement that has its own International Association. Highly acclaimed members of the International CoQ10 association have performed research on areas of:

Bioenergetics and electron transfer, Antioxidant aspects, Biosynthesis and metabolic aspects, Cardio-vascular disease, Diabetic Neuropathy, Brain Energy and many more topics. The results of these and other research performed on CoQ10 in Major Universities and Research Centers in the world is published after every International Conference on CoQ10.


CoQ10 was first isolated from beef heart mitochondria by Dr. Frederick Crane of Wisconsin, U.S.A., in 1957 (2). The same year, Professor Morton of England defined a compound obtained from vitamin A deficient rat liver to be the same as CoQ10(3). Professor Morton introduced the name ubiquinone, meaning the ubiquitous quinone. In 1958, Professor Karl Folkers and coworkers at Merck, Inc., determined the precise chemical structure of CoQ10: 2,3 dimethoxy-5 methyl-6 decaprenyl benzoquinone (Fig. 1), synthesized it, and were the first to produce it by fermentation. In the mid-1960's, Professor Yamamura of Japan became the first in the world to use coenzyme Q7 (a related compound) in the treatment of human disease: congestive heart failure. In 1966, Mellors and Tappel showed that reduced CoQ6 was an effective antioxidant (4,5). In 1972 Gian Paolo Littarru of Italy along with Professor Karl Folkers documented a deficiency of CoQ10 in human heart disease (6). By the mid-1970's, the Japanese perfected the industrial technology to produce pure CoQ10 in quantities sufficient for larger clinical trials. Peter Mitchell received the Nobel Prize in 1978 for his contribution to the understanding of biological energy transfer through the formulation of the chemiosmotic theory, which includes the vital protonmotive role of CoQ10 in energy transfer systems (7,8,9,10). 

In the early 1980's, there was a considerable acceleration in the number and size of clinical trials. These resulted in part from the availability of pure CoQ10 in large quantities from pharmaceutical companies in Japan and from the capacity to directly measure CoQ10 in blood and tissue by high performance liquid chromatography. Lars Ernster of Sweden, enlarged upon CoQ10's importance as an antioxidant and free radical scavenger (11). Professor Karl Folkers went on to receive the Priestly Medal from the American Chemical Society in 1986 and the National Medal of Science from President Bush in 1990 for his work with CoQ10 and other vitamins.

COENZYME Q10 DEFICIENCY

Normal blood and tissue levels of CoQ10 have been well established by numerous investigators around the world. Significantly decreased levels of CoQ10 have been noted in a wide variety of diseases in both animal and human studies. CoQ10 deficiency may be caused by insufficient dietary CoQ10, impairment in CoQ10 biosynthesis, excessive utilization of CoQ10 by the body, or any combination of the three. Decreased dietary intake is presumed in chronic malnutrition and cachexia(12). 

HMG-CoA reductase inhibitors used to treat elevated blood cholesterol levels by blocking cholesterol biosynthesis also block CoQ10 biosynthesis(13).

Increased body consumption of CoQ10 is the presumed cause of low blood CoQ10 levels seen in excessive exertion, hyper-metabolism, and acute shock states. It is likely that all three mechanisms (insufficient dietary CoQ10, impaired CoQ10 biosynthesis, and excessive utilization of CoQ10) are operable to varying degrees in most cases of observed CoQ10 deficiency.


 FREQUENTLY ASKED QUESTIONS

Over the past several years, there has been a steady increase in public interest and awareness of nutritional supplements and vitamins. Along with this accelerated interest has come an understandable explosion in the number and complexity of questions raised by patients about vitamins in general. 

1. What is CoQ10

It is a lipid-soluble vitamin-like substance present in every cell of the body and serves as a coenzyme for several of the key enzymatic steps in the production of energy within the cell. It also functions as an antioxidant which is important in its clinical effects. It is naturally present in small amounts in a wide variety of foods but is particularly high in organ meats such as heart, liver and kidney, as well as beef, soy oil, sardines, mackerel, and peanuts. To put dietary CoQ10 intake into perspective, one pound of sardines, two pounds of beef, or two and one half pounds of peanuts, provide 30 mg of CoQ10. CoQ10 is also synthesized in all tissues and in healthy individuals normal levels are maintained both by CoQ10 intake and by the body's synthesis of CoQ10. It has no known toxicity or side effects. 

2. Should I take CoQ10

In young and healthy people, the Liver makes 100% of the CoQ10 required. However, as we age this production is reduced and we will feel less energetic. 

3. What is the dosage of CoQ10 RED

A Soft gel of CoQ10 RED has 100 mg of Lipid Soluble CoQ10. Its absorption is significantly improved when it is taken with a fat-containing food, like walnuts or almonds. You can increase the dose gradually to feel the maximum energy required. Published data on the dosage of CoQ10 relates almost exclusively to the treatment of disease states.  Your physician can provide more accurate information on the dosage of CoQ10 required for each condition.

 

REFERENCES :   1. Gian Paolo Littarru (1994) Energy and Defense. Facts and perspectives on CoenzymeQ10 in biology and medicine. Casa Editrice Scientifica Internazionale, pp 1-91.   2. Crane F.L., Hatefi Y., Lester R.I., Widmer C. (1957) Isolation of a quinone from beef heart mitochondria. In: Biochimica et Biophys. Acta, vol. 25, pp 220-221.   3. Morton R.A., Wilson G.M., Lowe J.S., Leat W.M.F. (1957) Ubiquinone. In: Chemical Industry, pp 1649.   4. Mellors A., Tappel A.L. (1966) Quinones and quinols as inhibitors of lipid peroxidation. Lipids, vol. 1, pp 282-284.   5. Mellors A., Tappel A.L. (1966) The inhibition of mitochondrial peroxidation by ubiquinone and ubiquinol. J. Biol. Chem., vol. 241, pp 4353-4356.   6. Littarru G.P., Ho L., Folkers K. (1972) Deficiency of Coenzyme Q10 in human heart disease. Part I and II. In: Internat. J. Vit. Nutr. Res., 42, n. 2, 291:42, n. 3:413.   7. Mitchell P. (1976) Possible molecular mechanisms of the protonmotive function of cytochrome systems. In: J. Theoret. Biol., vol. 62, pp 327-367.   8. Mitchell P. (1991) The vital protonmotive role of coenzyme Q. In: Folkers K., Littarru G.P., Yamagami T. (eds) Biomedical and Clinical Aspects of Coenzyme Q, vol. 6, Elsevier, Amsterdam , pp 3-10.   9. Mitchell P. (1988) Respiratory chain systems in theory and practice. In: Advances in Membrane Biochemistry and Bioenergetics, Kim C.H., et al. (eds), Plenum Press, New York , pp 25-52.   10. Mitchell P. (1979) Kelin's respiratory ch

Instructions

Serving size:  1 softgel

Each bottle contains: 180 softgels

Directions: Take one softgel after breakfast. You can increase the dose after the first week to two softgels per day, either both after breakfast or one after breakfast and one after lunch. People who need more than 200 mg CoQ10 per day can take up to 4 softgels, two after breakfast and two after lunch. Consult your physician if you are taking blood-thinning medication. 

 

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Reviews

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Reviewed by gitya2000
gitya2000 bought "COQ10 RED :: 100 mg 180 CAPS" on our website
08/24/2011 - 09:24:07 AM
Magic pills COQ10
This Pills is wonderful I have to have it every day, my nick name at work is Bunny Energaizer keep going and going ( Battery Commercial) Realy COQ10 or Go Q10 gives me lots of energy. My husband take COQ10 also and he likes it.
Dr. Ershadi Thank you for all the good information and your hard work, You are a wonderful Doctor. At the end thank you for not charching us for copay.Just a joke....... Laugh.

Thanks,
G
Reviewed by tbsaghafi
08/09/2011 - 12:13:39 PM
tami saghafi
Thanks for this product, I have been using it for 2-3 years, it gives me energy and I sleep better now.
Reviewed by tbsaghafi
08/08/2011 - 10:48:12 AM
CoQ10 Red
I have been using this product for the past two years. It gives me much energy and I feel better. My sleep is much better now. I feel this product has worked on me internally since my bp has gone down adn my blood work shows improvements. Thank you for giving us the opportunity to have these products and use them to our benefits.
T. Saghafi
Reviewed by noushinm
noushinm bought "COQ10 RED :: 100 mg 180 CAPS" on our website
07/19/2011 - 01:12:52 PM
Great product
This is a great product which you'll thank yourself later for using it. All the antiaging products are amazing specially this one. Thank you for providing better health to us in such a simple and affordable way dr. Ershadi.
Reviewed by ExpressCheckoutUser
06/27/2011 - 10:14:33 PM
great product
before using coQ10, i always, always was wearied. Did not make any difference i slept 8 hours or 10 hours, i was tired and did not have energy. after using coQ10, gradually i felt beter and beter. then i felt that i want to dance with or without music, i talked a lot, i started to walked for 1 houre.2 months ago after examined by my cardialogiest, i was told that that i have no artery problem,which was a big relief. Thank you so much dear Dr. Shohre Ershaadi and staffs. with best regards. Homa Hashemi-Nejad
6/27/11 10:10 PM

Reviewed by kamyar21
kamyar21 bought "COQ10 RED :: 100 mg 180 CAPS" on our website
06/27/2011 - 04:42:03 PM
Invigorating supplement
This supplement is truly a great source of energy. I've been using this supplement for years ever since Dr. Ershadi made it available.

It not only helps relieve almost all my pains and aches but also provides me with a renewed sense of wellness.

Pari Yahyai from Virginia
Reviewed by AhooraSepand
06/18/2011 - 07:48:19 PM
Great stuff
This is really a great supplement and has helped me feel much better and energized.
Reviewed by gaboy
06/13/2011 - 05:58:49 PM
This product does magic
My name is Dave, I am 39 years old and I am a father of a little boy.
I had a weak heart muscle of unknown cause (idiopathic dilated cardiomyopathy) all my life.
I was always tired and weak even though I was taking all my medications regularly. I heard one of your programs on the Radio about CoQ10 Red.
I started taking CoQ10 Red one a day and after a few weeks I increased it to two per day one in the morning and one after lunch. My Heart function, as indicated by the fraction of blood pumped out of the heart with each beat (the ejection fraction), showed a gradual and sustained improvement as my Doctor was so surprised. Fatigue, chest pain, and palpitations are history now. The degree of improvement was so great my heart is normal now.
I play with my son, I run and swim without feeling tired. I have given CoQ10 Red to my parents as well and they love it too.
Reviewed by andriassian
andriassian bought "COQ10 RED :: 100 mg 180 CAPS" on our website
06/10/2011 - 01:26:41 PM
CoQ10
CoQ10 is a great supplement my family has been using it for years. All of the products of b4uage are outstanding.